Source: American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock. Crit Care Med 2017; 45:1061–1093
Monitoring Goals:
-
Capillary refill <2 or equal to 2 seconds
-
Normal pulses with no differential between the peripheral and central pulses,
-
Warm extremities,
-
Urine output greater than 1mL/kg/hr,
-
Normal mental status,
-
Normal blood pressure for age (only reliable when pulses palpable)
-
-
Normal SBP ranges (lowest 5th percentile)
-
-
0-1mos >60 mmHg
-
1 mos-1 yr >70 mmHG
-
1 yr -10 yr >70+ 2 x Age mmHg
-
>10 yr >90 mmHg
-
-
-
Blood Markers:
-
-
glucose concentration
-
-
Neonates < 45 mg/dL; infants/children < 60 mg/dL
-
Rule of 50 (or 100)
-
-
ionized calcium concentration
-
-
Calcium gluconate 100 mg/kg IV/IO (max 2g) PRN
-
-
Airway/Breathing
-
Etomidate not recommneded
-
-
Ketamine with consideration of atropine
-
Circulation
-
IO if pt >3kg
-
Fluid Bolus
-
-
10 ml/kg unto 1 mos old
-
20 ml/kg >1 mos old
-
May require up to. 60 ml/Kg
-
-
Vasopressors
-
-
Epinephrine
-
-
Considered first line
-
May run via PIV
-
Dilute 10x more than central solution
-
Run at 0.05–0.3 μg/kg/min
-
-
Dopamine
-
Hydrocortisone Therapy
-
Dose 2 mg/kg to max of 100 mg
-
If a child is “at risk of absolute adrenal insufciency or adrenal pituitary axis failure”
-
e.g., purpura fulminans, congenital adrenal hyperplasia, prior steroid exposure, hypothalamic/pituitary abnormality, intubation with etomidate induction
-
remains in shock despite epinephrine or norepinephrine infusion
-
after attaining a blood sample for subsequent determination of baseline cortisol concentration.