ESETT: A Randomized Trial of 3 AEDs for Status Epilepticus

Kapur, J et al. Randomized Trial of Three Anticonvulsants Medications for Status Epilepticus. NEJM 2019;381;2103-13 This was a randomized, double-blinded, national multicenter pragmatic study to determine comparative effectiveness of traditional anti-epileptic medications in status epilepticus. The purpose of this study is to see if there is a difference between levetiracetem (Keppra), fosphenytoin (Cerebyx), and valproate (Depakote) in treatment of […]

Stroke 2018 Update

In March New Stroke guidelines came out. Wow are they aggressive! tPA and endovascular therapy (EVT) for all… forget what the literature says! Well We NEED to know these so I’ve listed them here for reference. Sorry about the format. I’ll pretty it up soon! Stroke. 2018;49:e46–e99. DOI: 10.1161/STR.0000000000000158.) A primary goal of achieving door-to-needle (DTN) […]

Quick Hit Article #4: Aspirin NOT tPA for mild strokes – Big Pharma at it again…

Reference: Khatri P, Kleindorfer DO, Devlin T, et al. Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic DeficitsThe PRISMS Randomized Clinical Trial. JAMA. 2018;320(2):156–166. doi:10.1001/jama.2018.8496 I love me some stroke! However, nothing gets me as riled up as much as a good ole tPA for stroke study […]